Poster: Optimising Techniques to Investigate the Role of NKT Cells and Lipid Stimuli in Allergic Sensitisation

IgE-mediated allergies are increasing in prevalence, with IgE-mediated food allergies currently affecting up to 10% of children and 6% of adults worldwide. However, the mechanisms underpinning the first phase of IgE-mediated allergy, allergic sensitisation, are still not clear. Recently, the involvement of lipids in allergic sensitisation has been proposed. Current research suggests lipid-allergen interactions can influence a Th2 shift towards allergic sensitisation through the presentation of lipids via CD1d on DCs, activating NKT cells. However, there is limited research in this area, especially utilising human models of allergy. This research aims to optimise methods to efficiently study the effect of lipid stimuli on NKT cells in allergic sensitisation.

This poster was presented by Georgina V Hopkins (University of Nottingham).

View the poster here.


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