SOT 2018

Scientists from Unilever SEAC will be presenting different aspects of our research into non-animal approaches at the annual Society of Toxicology (SOT) meeting in San Antonio, Texas (11th-15th March, 2018). This will include a joint scientific session with the US Environmental Protection Agency (EPA), National Center for Computational Toxicology.

For full details of the event please visit the SOT website.

US EPA and Unilever Research Collaboration:
Accomplishments and Next Steps (Exhibitor-Hosted Session)
Wednesday, March 14, 9:00 AM to 10:00 AM, CC Room 217D

US EPA and Unilever are collaborating to use new tools and approaches to build a risk assessment to enable decisions to be made without using animal tests. This session will highlight the accomplishments of the collaboration to date and describe next steps. 

A series of posters shared at the 2018 Society of Toxicology annual meeting to highlight the key research areas being investigated within the Unilever – US EPA collaboration:

  • Overview of the joint research areas. Lead Authors, Paul Carmichael and Paul Russell, Unilever
  • Metabolism research for risk assessment. Lead Author, Mi-Young Lee, Unilever
  • QIVIVE for screening level risk assessment for a dermal Route of Exposure. Lead Author, Beate Nicol, Unilever
  • Using the EPA CompTox Dashboard to support a risk assessment. Lead Author, Wendy Simpson, Unilever
  • Using read-across in a risk assessment. Lead Author, Wendy Simpson, Unilever
  • Use of transcriptomics data for next generation risk assessment. Lead Authors, Andrew White and Sophie Malcomber, Unilever
  • In vitro assays in mechanistic risk assessment. Lead Author, Sharon Scott, Unilever
  • Retrofitting an Estrogen Receptor Transactivation Assay with Metabolic Competence Using Alginate Immobilization of Metabolic Enzymes (AIME). Lead Author, Danica DeGroot, US EPA
  • Differential gene expression and concentration-response modeling workflow for high-throughput transcriptomic (httr) data: results from mcf7 cells. Lead Author, Joshua Harrill, US EPA
  • Application of a multiplexed high content imaging (HCI) based cell viability and apoptosis chemical screening assay with results in MCF-7 cells. Lead Authors, Clinton Willis and Joshua Harrill, US EPA


Monday, March 12, 9:15 AM to 12:00 Noon
Toxicology’s Next Grand Challenge: Embracing Exposure Science for Effective Public Health Protection (Workshop Session)
The Importance of Exposure Considerations in Safety Assessment. Presented by​ Andrew Scott

Monday, March 12, 1:45 PM to 4:30 PM
Chemical Grouping for 21st-Century Toxicology, Risk Assessment, and Decision Making (Symposium Session)
Using Chemical Categories to Inform Quantitative Risk Assessment. ​Presented by Tim Allen


Poster Board P270
High-Throughput Microscopy of Cellular Stress Response Activation Identifies Tipping Points for Nrf2 and NfκB Signaling Cross-Talk. ​​B. ter Braak, A. Klip, S. Hiemstra, S. Wink, A. Middleton, A. White, and B. van de Water

Poster Board P876
Evaluation of a Next-Generation Risk Assessment (NGRA) Approach for Skin Allergy Using Six Ingredients and Two Product Exposure Scenarios.G. Maxwell, N. Aptula, M. Baltazar, J. Butcher, R. Cubberley, N. Gilmour, C. MacKay, R. Pendlington, J. Reynolds, E. Vandenbossche, and C. Westmoreland.