SOT 2016

Scientists from Unilever SEAC will be presenting different aspects of our research into non-animal approaches at the annual Society of Toxicology (SOT) meeting in New Orleans, Louisiana (13th-17th March, 2016). This will include a joint scientific session with the US Environmental Protection Agency (EPA), and presentations in the SOT scientific sessions and continuing education program. Details of oral presentations and posters can be found below.
For full details of the event please visit the SOT website.

US EPA and Unilever Present New Research Collaboration to Advance Non Animal Approaches for Chemical Risk Assessment
Monday, 14th March, 9:00 AM to 10:00 AM, room 205
Talks from Prof Paul Carmichael and Dr Rusty Thomas



Sunday, March 13th, 8:15 AM to 12:00 Noon Continuing Education
Applying AOPs to the Development of Integrated Approaches to Testing and Assessment (IATA). Presented by Dr. Gavin Maxwell.

Monday, March 14, 2:00 PM to 4:45 PM Moving Beyond Prioritization towards True in Vitro-Based Safety Assessment
Integrating Biokinetics and Biodynamics for Consumer Safety Assessment Using Quercetin as a Case Study. Presented by Yeyejide Adeleye.

Wednesday, March 16, 10:00 AM to 12:15 PM NRF2 in Redox Biology
The Development of a Mechanistic Systems Biology Model for Nrf2 and Oxidative Stress to Understand Homeostatic Control and Adaptive Responses to Low Doses of Oxidative Compounds. Presented by Dr Sarah Cooper.

Wednesday, March 16, 2:00 PM to 4:45 PM High-Content Imaging for Predictive Toxicology: Discriminating between Adverse and Adaptive Outcomes
Utilizing High Content Imaging Tools Towards Pathways-Based Safety Assessments: a Consumer Product Industry Perspective. Presented by Prof. Paul Carmichael.


Tuesday, March 15, 1:15 PM to 4:30 PM Cell and Organ-on-a-Chip Models
Assessment of Androgenic and Anti-androgenic Activity Using RWPE-1 Prostate Microtissues. M. Ventangoli, S. Madnick, S. Wilson, M. Dent, P.L. Carmichael, K. Boekelheide.

Tuesday, March 15, 1:15 PM to 4:30 PM Biological Modelling
Oxidative Stress Response – Predicting adaptive to adverse transition. S. Das, R. Kumar, A. Khanna, M.K. Narasimha, B. Thota, K. Rajendran, D. Raman, V. Rajagopalan, N. Dharwar, G.V. Balamurali, G. Jain, S. Cooper, A. Middleton, S. Glavin, A. White.

Tuesday, March 15, 1:15 PM to 4:45 PM 3D Cell and Organ-on-a-Chip Model
Molecular Initiating Events in toxicity pathways using organotypic human in vitro models. P. Fowler, S. Scott, S. Malcomber, P. Walker, S. Ravenscroft, C. Bauch, P. Russell.

Wednesday, March 16, 09:30 AM to 12:45 PM Computational and Systems Toxicity II
Mechanistic Model-Based Approach to Skin Sensitization Risk Assessment. G. Maxwell, R. Cubberley, S. Dhadra, N. Gellatly, J. Gosling, R. Pendlington, J. Pickles, J. Reynolds, R. Stark, D. Tang, C. MacKay.

Wednesday, March 16, 1:15 PM to 16:45 Alternative In Vitro Toxicity Models
Developing a mitochondrial toxicity pathway-based framework for chemical safety assessment: a case study of PGC-1α-mediated network perturbation with doxorubicin. H. Yuan, Q. Zhang, J. Guo, T. Zhang, J. Li, P. Carmichael, A. White, C. Westmoreland, J. Zhao, S. Peng.

Wednesday, March 16, 1:15 PM to 4:45 PM Alternative In Vitro Toxicity Models
Dose Response Studies Supporting in Vitro-Based Safety Assessments for Chemicals Including Oxidative Stress. B. Huang, S.M. Ross, S. Rowley, A. Efremenko, S. Pendse, L. Pluta, P. Xue, J. Pi, P.L. Carmichael, A. White, R.A. Clewell.