Workshop on Mitochondrial Toxicity and Pathway-Based Chemical Safety Assessment

An inaugural symposium of the Society of Toxicological Alternatives and Translational Toxicology, CSOT


This workshop provides an unprecedented opportunity for scientists across US, EU and China to discuss up-to-date research developments in the novel non-animal approaches and to address challenges linking to the recent advances in 21PstP century safety assessments (e.g., pathways-based approaches to toxicity testing (TT21C) and mechanism-focused approaches to risk assessment (adverse outcome pathways – AOPs)). The programme will aim to call for further contributions and creativity from Chinese scientists, in collaboration with scientists across the world, to accelerate this paradigm shift in toxicology with case studies in mitochondrial toxicity.

Date: Monday 13th Oct. – Tuesday 14th October 2014.

Venue: No. 9 Dacheng Road Hotel, Beijing, China.

Host: Chinese Society of Toxicology (CSOT)

Organizers: Institute of Disease Control and Prevention, Academy of Military Medical Sciences and Unilever.

A full listing of lectures and discussions can be found in the Workshop Program.

Plenary Lectures:

A summary of the lecture abstracts and speaker profiles can be found in the Plenary Lecture Abstracts.

Monday 13th October





09:00 – 09:30

Toxicological alternatives and translational toxicology: opportunities and challenges.
Prof. Shuangqing Peng
The Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing
Weidong Hao and Jing Ma

09:30 – 10:00

TT21C/AOPs: putting mechanism and toxicity pathways at the heart of new safety assessments
Prof. Paul Carmichael
Safety and Environmental Assurance Centre (SEAC), Unilever, UK

10:00 – 10:30

US Tox21 program: application of qHTS approach for assessment of mitochondrial toxicity
Dr. Menghang Xia
National Center for Advancing Translational Sciences, National Institutes of Health, USA

10:30 – 10:45

Coffee Break

10:45 – 11:15

Metabolically-modified liver models to examine the role of mitochondrial dysfunction in drug-induced liver injury and their relevance to man
Dr Amy Chadwick
Institute of Translational Medicine, The University of Liverpool, UK
Weidong Wu and Jin Li

11:15– 11:45

Computational system biological modeling and its role in pathway-based mitochondrial toxicity assessment
Dr. Qiang Zhang
Institute for Chemical Safety Sciences, The Hamner Institute for Health Sciences, USA

11:45 – 12:15

Stress induced cardiovascular injury: from protein change to mitochondrial dysfunction.
Dr. Lingjia Qian
The Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing
Tuesday 14th October





08:00 – 08:30 The role of 21st century toxicology in refining Environmental Risk Assessment
Dr. Steve Gutsell
Safety and Environmental Assurance Centre (SEAC), Unilever, UK
Hua Li and Bolin Fan
08:30 – 09:00 High content-based cellular phenotypic assay platform and its application in drug mitochondrial toxicity research.
Dr. Lili Wang
The Institute of Pharmacology and Toxicology, AMMS, Beijing
09:00 – 09:30 In vitro approaches to assess mitochondrial toxicity and mitochondria-mediated drug toxicity: A decade of learning
Dr. Yvonne Will
Cell Based Assays and Mitochondrial Biology, Pfizer R&D, USA
09:30 – 10:00 Release of Cyt c from mitochondria by methylated arsenic occurs through interaction with voltage dependent anion channel in vitro.
Dr. Hua Naranmandura
School of Medicine and Public Health, Zhejiang University
10:00 – 10:15 Coffee Break
10:15 – 10:45 MIES and mitochondrial toxicity – the applied view
Dr. Paul Russell
Safety and Environmental Assurance Centre (SEAC), Unilever, UK
Zhengtao Liu and Peiyu Xu
10:45 – 11:15 TT21C and AOP: cumulative benzo(a)pyrene exposure toxicological research.
Dr. Hui Wang
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
11:15 – 11:45 Enhancing non-testing approaches using the AOP framework: a case study in building scientific confidence
Dr. Grace Patlewicz
DuPont Haskell Global Centre for Health and Environmental Sciences, USA