Presentation: Computational Methods in Next-Generation Risk Assessment of Consumer Products

The use of computational models is common-place across the consumer product development pipeline as ‘in-silico first’ applies to almost all areas of efficacy and safety. Safety assessments of novel chemicals (or novel uses of existing chemicals) is required to cover human exposure and release to the environment. A key principle is that modern risk assessments should be exposure led and quantitative, so that predictions relating to dose may be interpretable in the context of exposure. Interpreting outputs from in vitro assays requires an understanding of both cellular exposure and how these relate to in vivo internal concentrations. The concept of exposure-led risk assessment allows methods to identify and characterize hazard and risk to be applied in a tiered manner starting with application of thresholds, e.g. Threshold of Toxicological Concern (TTC), Dermal Sensitization Threshold (DST) or Ecological Threshold for Toxicological Concern (ecoTTC) and building through in silico, in chemico and in vitro assays combined in weight of evidence assessments. The concept and benefits of pathways-based approaches to risk assessment will also be presented in an applied context for both environmental and human health risk assessment. Attendees will learn the following from this presentation:
• The importance of understanding exposure at the in vitro and in vivo level for human and environmental risk assessment
• How pathways-based approaches, e.g. Adverse Outcome Pathways, are used in risk assessment of consumer products
• Areas of commonality between environmental and human health risk assessment

Presented as part of a continuing education session at Society of Toxicology (SOT) 2019 Conference on Computational Toxicology.

View the presentation here.

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