New Posters: Towards Application of Next Generation Risk Assessment in Food Safety Risk Assessment

Next generation risk assessment (NGRA) is an exposure-led risk assessment approach. Based on mechanistic understanding of chemico-biological interactions, it uses a range of in vitro and in silico approaches to generate dose response data and internal exposure data for risk assessment without any animal tests. As a starting point to introduce risk assessment without animal tests, a case study regarding risk assessment for camomile as a tea ingredient is introduced, in which, only history of safe use data and existing animal/human toxicological data are used for the risk assessment. To demonstrate the application of a range of in vitro and in silico approaches in NGRA, a hypothetical case study regarding the risk assessment of coumarin as an ingredient of a soy sauce is proposed. In this case study, only internally and externally sourced in silico, in chemico and in vitro data were used for the risk assessment, while all the known animal or human clinical data, in addition to history of use data, was excluded. In addition, read-across approaches that use these excluded data were not used.

View poster 1, Towards Application of Next Generation Risk Assessment in Food Safety Risk Assessment, here.

View poster 2, Risk Assessment of novel food ingredient using non-animal methods: Camomile as an example, here.

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