International Scientific Workshop on Non-animal Approaches for Chemical Safety: Celebrating Success and Enhancing Cooperation

化学物安全非动物方法国际科学研讨会 – 分享收获 竭诚合作

Date: Wednesday 10th April – Thursday 11th April 2019. (2019年4月10日至11日)

Host: Unilever China Consumer Product Safety Collaboration Centre (UCCPSCC) (联合利华中国消费者产品安全合作中心)

Organisers: Sandy Li 李支霞, Jie-Bing Zhu 朱介兵, Jin Li 李津, Paul Carmichael & Carl Westmoreland

Only invited participants can join this meeting. Please contact one of the most appropriate workshop organisers.  仅限受邀者参加。请联系合适的研讨会组织者。

The Unilever China Consumer Product Safety Collaboration Centre (UCCPSCC) is proud to present its scientific workshop to bring together our current and future multidisciplinary collaborators or partners in China across academia, industry, and regulatory bodies to share their knowledge and experiences in applying non-animal (in vitro and in silico) methods for chemical and product safety assessment. 联合利华中国消费者产品安全合作中心(UCCPSCC)很荣幸能够与现有的及未来可能成为我们合作伙 伴共同举办本次跨学科研讨会。来自学术界、工业界及监管机构的知名学者及代表与我们齐聚一堂, 共同分享非动物(体外方法和计算机模型)新技术方法应用在化学物和产品安全评估方面的丰富成果及 实际经验,加强参会者彼此之间进一步的协调合作,共创未来。

Program: (会议日程)

A full listing of lectures and discussions can be found in the Workshop Program. A summary of the key sessions is available below:

Wednesday 10th April 2019 (2019年4月10日,星期三)

Time Session
9:00 – 9:10 Welcome and Introduction –  (VP R&D Unilever China)
开幕式 –  (联合利华中国研发领导)
9:10 – 9:15 Setting the theme (meeting expectation) – Jin Li (Unilever)
会议主题及展望 – 李津(联合利华)
9:15 – 9:40 Safety assessment without animals – scientific progress since 2011 – Carl Westmoreland (Unilever)
无动物安全评估 – 自2011年以来的科学进步 – (联合利华)
9:40 – 10:05 Development and application of non-animal toxicity testing in China – Shuangqing Peng (President of TATT/CSOT)
中国非动物替代技术的发展及应用 – 彭双清(替代法与转化毒理学专委会主任)
10:05 – 10:30 A framework for non-animal next generation risk assessment (NGRA) for cosmetic chemical safety – Paul Carmichael (Unilever)
化妆品化学安全性的非动物下一代风险评估(NGRA)框架 – (联合利华)
10:30 – 10:55 A tiered pathway approach in an exposure-led framework for NGRA – Jiabin Guo (Academy of Military Medical Science)

下一代风险评估:暴露量驱动的分层毒理通路方法- 郭家彬(军科院)

11:15 – 11:40 Multi-omics studies for chemical risk assessment- Ping Xu (Beijing Proteomics Research Centre)
化学风险评估中的多组学研究- 徐平(北京蛋白质组研究中心)
11:40 – 12:05 Predictive toxicology: from and beyond structural basis –

Aiqian Zhang (Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences)
预测毒理学:基于与超越化学结构- 张爱茜(科学院生态环境中心)

12:05 – 12:30 In-vitro safety pharmacology screening in preclinical phase of drug discovery: overview of pharmaron’s research platform – Lei 及Wen (Pharmaron)
药物临床前的体外安全药理学筛选: 康龙化成研究平台概述 –

温磊(康龙化成)

13:30 – 13:55 3d models and non-animal safety evaluation of cosmetics – Ying Yang (GD-CDC)
3D器官模型在化妆品非动物测试评价中的应用研究– 杨颖(广东-疾控所)
13:55 – 14:20 Application of alternative methods to cosmetic safety and personal thoughts – Rong Kuang (Zhejiang -IFDC)

化妆品替代毒理的实践与思考 – 匡荣 (浙江食品药品检验研究院)

14:20 – 14:45 Toxicology alternatives education in china – Weidong Hao (Peking University)
中国毒理学替代法教育- 郝卫东 (北京大学)
14:45 – 14:55 Introduction to group discussions (Jin Li / Paul Carmichael)
小组讨论简介 (李津 / Paul Carmichael)
15:30 – 16:30 Breakout session: 5 groups to discuss questions
分组会议:5个小组讨论问题
16:30 Closing of meeting & Photo taken together
会议结束、合影留念

Thursday 11th April 2019 (2019年4月11日,星期四)

Time Session
8:30 – 8:45 Thoughts on Day 1 into NGRA and Intro to Day 2
第1天报告总结NGRA的感想和第2天会议日程的介绍

– Jin Li / Paul Carmichael

8:45 – 9:10 3D eye irritation models for cosmetic products – Yongbo Lu (BioCell)
3D眼刺激性检测体系在化妆品行业中的应用-  卢永波(博溪生物)
 9:10 – 9:35  Organs-on-chips platform to advance chemical safety assessment – Jianhua Qin (Dalian Institute of Chemistry Physics / CAS)
提升化学物安全评估器官芯片平台- 秦建华(中科院大连)
9:35 – 10:00 Bio-printing in vitro physiological model for drug testing – Wei Sun (Tsinghua University)
生物打印体外组织模型及在药毒理检测的应用-  孙伟(清华大学)
10:20 – 10:45 Assays for safety mechanisms: how to interpret the data on cellular adaptive stress responses? – Jingbo Pi (China Medical University)
安全机制实验:如何解释细胞适应性应激反应的数据?-  皮静波(中国医科大学)
10:45 – 11:10 Dose-dependent transcriptomic approach for screening and prediction of chemical toxicity – Xiaowei Zhang (Nanjing University)

基于剂量转录组学方法在筛选及预测化学物毒性中的应用- 张效伟(南京大学)

11:10 – 11:35 Integrated approaches to testing and assessment– Quanshun Zhang (Institute for In Vitro Science)
测试和评估的整合方法策略- 张全顺(美国体外研究院)
11:35 – 12:05 5 Group reporting back (5 mins for each group)
5个小组汇报(每组5分钟)
12:05 – 12:30 Further discussions (challenges and opportunities) 进一步讨论
12:30 – 12:40 Wrap-up, next steps and thanks to all – Carl Westmoreland (Unilever)

总结、下一步计划、致谢词

12:40 – 12:45 Formal closure of meeting – Jiebing Zhu

会议正式结束 – 朱介兵 (Unilever)

Suggested Pre-read: 建议预读

Unilever Publications: (联合利华发表刊物)

Dent, M; et. al. (2018) Principles underpinning the use of new methodologies in the risk assessment of cosmetic ingredients, Computational Toxicology, Volume 7, P20-26, ISSN 2468-1113, https://doi.org/10.1016/j.comtox.2018.06.001.

Reynolds. J. et. al. (2019) Probabilistic prediction of human skin sensitiser potency for use in next generation risk assessment. Computational Toxicology. Volume 9, P 36-49, ISSN 2468-1113, https://doi.org/10.1016/j.comtox.2018.10.004.

Dent, M; et. al. (2019) Employing Dietary Comparators to Perform Risk Assessments for Anti-Androgens Without Using Animal Data. Toxicological Sciences. https://doi.org/10.1093/toxsci/kfy245

Poster 1: A framework for NGRA

Poster 2: Next generation risk assessment (NGRA): bridging in vitro points-of-departure to human safety assessment using physiologically-based  pharmacokinetic (PBPK) modelling – a case study with doxorubicin

Poster 3: Coumarin: Application of an NGRA Framework to a Hypothetical Case Study.

Other Relevant Publications: (其它发表刊物)

ICCVAM (Interagency Coordinating Committee on the Validation of Alternative Methods). (2018). A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States. https://dx.doi.org/10.22427/NTP-ICCVAM-ROADMAP2018

National Academies of Sciences, Engineering, and Medicine. (2017) Using 21st Century Science to Improve Risk-Related Evaluations. Washington, DC: The National Academies Press. https://doi.org/10.17226/24635.

US FDA (2017), FDA’s Predictive Toxicology Roadmap.
https://www.fda.gov/ScienceResearch/AboutScienceResearchatFDA/ucm601090.htm